Description

tert-Butyl (3R)-3-Fluoro-4-oxopiperidine-1-carboxylate is a high-purity, chiral fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing a stereodefined fluorine atom and a protected amine functionality into complex molecular architectures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and kinase modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorine substitution on potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel fluorinated pesticides and herbicides with enhanced activity.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and pharmacological research.
• Process Chemistry & Scale-up: Suitable for use in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl (3R)-3-Fluoro-4-oxopiperidine-1-carboxylate
CAS No.	1266339-10-9
Molecular Formula	C10H16FNO3
Molecular Weight	217.24 g/mol
Synonyms	1-Boc-3R-fluoro-4-piperidinone; (3R)-1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidinone; (R)-1-Boc-3-fluoro-4-piperidone; tert-Butyl (3R)-3-fluoro-4-oxo-1-piperidinecarboxylate; (R)-3-Fluoro-1-N-Boc-4-piperidone; 1-N-Boc-(3R)-fluoro-4-piperidone; 4-Piperidinone, 3-fluoro-1-[(1,1-dimethylethoxy)carbonyl]-, (3R)-; BOC-(R)-3-fluoro-4-piperidone
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-3-Fluoro-4-oxopiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.