Description

3-(5-Bromo-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, offering a protected amine and a versatile halogenated pyridine moiety for further functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a key starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of specialized compounds for clients.
• Agrochemical Research: Potential application as an intermediate in the development of novel crop protection agents and pesticides.
• Ligand Synthesis: Can be utilized in the preparation of specialized ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	3-(5-Bromo-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1266115-14-3
Molecular Formula	C17H25BrN2O3
Molecular Weight	385.30 g/mol
Synonyms	1-Boc-3-[(5-bromo-2-pyridyloxy)methyl]piperidine; tert-Butyl 3-[(5-bromopyridin-2-yl)oxymethyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(5-bromo-2-pyridinyloxy)methyl]piperidine; 3-[(5-Bromo-2-pyridyloxy)methyl]-1-N-Boc-piperidine; N-Boc-3-((5-bromopyridin-2-yloxy)methyl)piperidine; 3-((5-Bromopyridin-2-yloxy)methyl)piperidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-((5-bromo-2-pyridyloxy)methyl)piperidine; 3-(5-Bromo-2-pyridyloxymethyl)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(5-Bromo-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured under GMP-like conditions suitable for pharmaceutical research and is subjected to comprehensive analytical testing, including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.