Description

1-Oxa-6-Azaspiro[3,4]Octane-6-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the creation of tool compounds for investigating biological pathways and target validation.
• Process Chemistry: Used in route scouting and scale-up synthesis for the commercial manufacturing of APIs.
• Academic Research: A valuable reagent for synthetic organic chemistry and methodology development in university and institutional labs.

Basic Information

Product Name	1-Oxa-6-Azaspiro[3,4]Octane-6-Carboxylic Acid tert-Butyl Ester
CAS No.	1264635-65-5
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 1-oxa-6-azaspiro[3.4]octane-6-carboxylate; 6-Boc-1-oxa-6-azaspiro[3.4]octane; 1-Oxa-6-azaspiro[3.4]octane-6-carboxylic acid, 1,1-dimethylethyl ester; 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[3.4]octane; Boc-1-oxa-6-azaspiro[3.4]octane; 1-Oxa-6-azaspiro[3,4]octane-6-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Oxa-6-Azaspiro[3,4]Octane-6-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, and our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.