Description

Delgocitinib is a potent and selective Janus kinase (JAK) inhibitor, a class of compounds with significant therapeutic potential. Its primary value lies in its targeted mechanism of action, which modulates key signaling pathways involved in inflammatory and autoimmune responses. This makes it a critical intermediate and active pharmaceutical ingredient (API) for research and development in the pharmaceutical industry. Key stakeholders include pharmaceutical manufacturers, biotechnology firms, and contract research organizations (CROs) focused on developing novel treatments for dermatological and immunological conditions.

Application

• Primary use as a key Active Pharmaceutical Ingredient (API) in the formulation of topical and systemic JAK inhibitor therapies.
• Critical research chemical for preclinical and clinical studies investigating new treatments for atopic dermatitis, psoriasis, and other inflammatory skin diseases.
• Used as a high-purity reference standard in analytical laboratories for quality control and method development.
• Essential chemical intermediate in the synthetic pathway for more complex JAK-targeting drug candidates.
• Valuable tool compound in pharmacological research to study JAK-STAT signaling pathways and their role in immune regulation.

Basic Information

Product Name	Delgocitinib
CAS No.	1263774-59-9
Molecular Formula	C₂₀H₂₃N₇O
Molecular Weight	377.45 g/mol
Synonyms	JTE-052; (3S,4R)-3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-N-(2,2,2-trifluoroethyl)-4-piperidinecarboxamide; Delgocitinib (JTE-052); JTE 052; 4-[1-[(3S,4R)-4-[[2,2,2-Trifluoroethyl]carbamoyl]-3-piperidyl]pyrazol-4-yl]pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our Delgocitinib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and relevant ICH guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities: ≤2.0% Any single impurity: ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.