Description

4-Bromo-2-(Trifluoromethyl)Pyridine Hydrobromide is a high-purity, halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique trifluoromethyl and bromine substituents, which are essential for modulating the electronic and steric properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Employed as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeling reagents in biochemical research.
• Cross-Coupling Reactions: Acts as a reliable electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects on behalf of global clients.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Pyridine Hydrobromide
CAS No.	1263378-63-7
Molecular Formula	C6H4BrF3N • HBr
Molecular Weight	300.92 g/mol (Free base: 225.99 g/mol)
Synonyms	2-(Trifluoromethyl)-4-bromopyridine Hydrobromide; 4-Bromo-2-(trifluoromethyl)pyridine HBr; 4-Bromo-α,α,α-trifluoro-2-picoline Hydrobromide; Pyridine, 4-bromo-2-(trifluoromethyl)-, hydrobromide; 4-Bromo-2-trifluoromethylpyridine Hydrobromide Salt
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Pyridine Hydrobromide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.