Description

(1R,2R)-2-(3-Chloropyridin-4-Yl)Cyclopropanecarboxylic Acid CAS NO 1263284-68-9 is a high-purity, chiral cyclopropane derivative featuring a chloropyridine moiety, serving as a critical advanced pharmaceutical intermediate (API). Its value lies in its precise stereochemistry and functional groups, which are essential for constructing complex bioactive molecules with targeted therapeutic effects. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active ingredients, particularly for central nervous system (CNS) and antiviral applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially for neurological and antiviral targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final or penultimate steps of manufacturing complex, stereospecific APIs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Asymmetric Synthesis: Utilized as a chiral synthon to introduce the cyclopropane scaffold into molecules, imparting conformational rigidity.
• Contract Development & Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial drugs.
• Bioconjugation & Probe Development: The carboxylic acid group allows for conjugation to carriers, labels, or other molecules for diagnostic or research tools.

Basic Information

Product Name	(1R,2R)-2-(3-Chloropyridin-4-Yl)Cyclopropanecarboxylic Acid
CAS No.	1263284-68-9
Molecular Formula	C9H8ClNO2
Molecular Weight	197.62 g/mol
Synonyms	(1R,2R)-2-(3-Chloro-4-pyridinyl)cyclopropanecarboxylic acid; (1R,2R)-rel-2-(3-Chloro-4-pyridinyl)cyclopropanecarboxylic Acid; (1R,2R)-2-(3-Chloropyridin-4-yl)cyclopropane-1-carboxylic acid; (1R,2R)-2-(3-Chloro-4-pyridyl)cyclopropanecarboxylic Acid; (1R,2R)-2-(3-Chloro-pyridin-4-yl)-cyclopropanecarboxylic acid; 2-(3-Chloropyridin-4-yl)cyclopropanecarboxylic Acid (1R,2R)-; UNII-7J2H4Q4R4F; 7J2H4Q4R4F
EINECS	Contact for details

Quality Control

Our (1R,2R)-2-(3-Chloropyridin-4-Yl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is stable under inert atmosphere in strong acid/organic solvent conditions but should be kept away from incompatible materials. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.