Description

(5R,7S)-Benzyl 7-Methyl-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic diazepane scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel therapeutic agents. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of central nervous system (CNS) drugs, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its constrained, three-dimensional spirocyclic structure.
• Protease Inhibitor Development: The diazaspiro[4.5]decane core is a privileged structure in the design of inhibitors for various enzymes, including kinases and proteases.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	(5R,7S)-Benzyl 7-Methyl-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate
CAS No.	1263284-47-4
Molecular Formula	C17H22N2O3
Molecular Weight	302.37 g/mol
Synonyms	Benzyl (5R,7S)-7-methyl-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate; 8-CBz-7-methyl-3-oxo-2,8-diazaspiro[4.5]decane; (5R,7S)-7-Methyl-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid benzyl ester; UNII-7VQ6S5A8J2; Spirocyclic diazepane carboxylate; Bn-Protected diazaspirodecane intermediate
EINECS	Contact for details

Quality Control

Every batch of (5R,7S)-Benzyl 7-Methyl-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for advanced research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.