Description

Ethyl 6-(2,2,2-Trifluoroethoxy)Nicotinate is a high-value fluorinated nicotinate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic incorporation of the trifluoroethoxy moiety, which can significantly alter the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients requiring enhanced metabolic stability, lipophilicity, or bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoroethoxy group can improve pesticidal activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry for creating novel ligands that modulate catalyst performance in cross-coupling and fluorination reactions.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of fluorine and fluoroalkoxy groups on reaction mechanisms and molecular conformation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale cGMP batches for clinical trials.

Basic Information

Product Name	Ethyl 6-(2,2,2-Trifluoroethoxy)Nicotinate
CAS No.	1263276-73-8
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	Ethyl 6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(2,2,2-trifluoroethoxy)-, ethyl ester; 6-(2,2,2-Trifluoroethoxy)nicotinic acid ethyl ester; Ethyl 6-(trifluoroethoxy)nicotinate; 6-Trifluoroethoxynicotinic acid ethyl ester; 6-OCH2CF3 Nicotinic Acid Ethyl Ester; 3-Carbethoxy-6-(2,2,2-trifluoroethoxy)pyridine
EINECS	Contact for details

Quality Control

Our Ethyl 6-(2,2,2-Trifluoroethoxy)Nicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for research and development, as well as non-GMP scale-up synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.