Description

tert-Butyl 1-Fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate is a high-value, fluorinated spirocyclic amine building block designed for advanced pharmaceutical research and development. This compound is a critical intermediate in medicinal chemistry, offering a unique three-dimensional scaffold that can enhance the potency, selectivity, and metabolic stability of drug candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents targeting central nervous system (CNS) disorders, oncology, and other complex disease areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in CNS drug discovery programs.
• Medicinal Chemistry Scaffold: Utilized to explore structure-activity relationships (SAR) due to its constrained spirocyclic and fluorinated structure, which can improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Used in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of candidate drugs.
• Library Synthesis: A valuable input for creating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 1-Fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate
CAS No.	1263178-12-6
Molecular Formula	C14H25FN2O2
Molecular Weight	272.36 g/mol
Synonyms	1-Fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester; tert-Butyl 1-fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate; 3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 1-fluoro-, 1,1-dimethylethyl ester; 1-Fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylic acid 1,1-dimethylethyl ester; 1263178-12-6; FC-3030 (Potential R&D code); FDUC tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Fluoro-3,9-diazaspiro[5.5]undecane-3-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for use in pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.