Description

10-Fluoro-2,7-Diaza-Spiro[4.5]Decane-7-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and diaza scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for synthesizing potential drug candidates, especially those requiring a constrained, fluorine-containing spirocyclic amine motif.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to modulate pharmacokinetic properties like metabolic stability and bioavailability.
• Synthesis of CNS-Active Compounds: The structural features make it valuable for creating molecules intended to cross the blood-brain barrier for targets in neurology and psychiatry.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against various disease targets.
• Process Chemistry Development: Used during scale-up and route scouting for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glues: The amine and ester functionalities make it a potential component in the synthesis of novel heterobifunctional degraders.

Basic Information

Product Name	10-Fluoro-2,7-Diaza-Spiro[4.5]Decane-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1263177-23-6
Molecular Formula	C13H23FN2O2
Molecular Weight	258.34 g/mol
Synonyms	tert-Butyl 10-fluoro-2,7-diazaspiro[4.5]decane-7-carboxylate; 7-(tert-Butoxycarbonyl)-10-fluoro-2,7-diazaspiro[4.5]decane; 10-Fluoro-2,7-diazaspiro[4.5]decane-7-carboxylic acid 1,1-dimethylethyl ester; 10-Fluoro-7-Boc-2,7-diazaspiro[4.5]decane; F-Spiro[4.5]Diaza-Boc; Boc-Protected 10-Fluoro-2,7-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our production of 10-Fluoro-2,7-Diaza-Spiro[4.5]Decane-7-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediate applications, ensuring traceability and reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.