Description

1,1-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs), making it a critical building block in modern drug discovery. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms and rigid spirocyclic scaffolds into lead compounds.
• API Development: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients.
• Biochemical Tool Compound: Utilized in pharmacological research as a standard or probe to investigate specific biological pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for clinical trial material production.
• Fluorine Chemistry Applications: Acts as a versatile difluoromethylene source or building block in specialized organic synthesis.

Basic Information

Product Name	1,1-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride
CAS No.	1263132-31-5
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	6-Azaspiro[2.5]octane, 1,1-difluoro-, hydrochloride; 1,1-Difluoro-6-azaspiro[2.5]octane HCl; 1,1-Difluoro-6-azaspiro[2.5]octane hydrochloride; 1,1-Difluoro-6-azaspiro[2.5]octane monohydrochloride; 6-Azaspiro[2.5]octane, 1,1-difluoro-, monohydrochloride; 1263132-31-5; 1,1-Difluoro-6-azaspiro[2.5]octane, hydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-6-Azaspiro[2.5]Octane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep away from incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.