Description

Ethyl (R)-n-Cbz-3-Pyrrolidinecarboxylate is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound is a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for chiral drugs targeting the central nervous system and other therapeutic areas. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in the production of complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those containing pyrrolidine or proline scaffolds.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and peptidomimetics for drug discovery programs.
• Asymmetric Synthesis: Serves as a versatile starting material for the preparation of enantiomerically pure compounds via various catalytic and stoichiometric transformations.
• API Process Development: Employed in route scouting and scale-up processes for the manufacture of Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry: Provides a protected, stereodefined handle for introducing the (R)-3-pyrrolidinecarboxylic acid moiety into novel molecular entities.
• Custom Synthesis & Contract Manufacturing: A valuable building block for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	Ethyl (R)-n-Cbz-3-Pyrrolidinecarboxylate
CAS No.	1263078-10-9
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	(R)-1-[(Benzyloxy)carbonyl]-3-pyrrolidinecarboxylic Acid Ethyl Ester; (R)-1-Cbz-3-pyrrolidinecarboxylic Acid Ethyl Ester; Ethyl (R)-1-(Benzyloxycarbonyl)-3-pyrrolidinecarboxylate; (R)-N-Carbobenzoxy-3-pyrrolidinecarboxylic Acid Ethyl Ester; (R)-N-Cbz-3-pyrrolidinecarboxylic Acid Ethyl Ester; (R)-1-[(Phenylmethoxy)carbonyl]-3-pyrrolidinecarboxylic Acid Ethyl Ester; Ethyl (3R)-1-{[(benzyloxy)carbonyl]}pyrrolidine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl (R)-n-Cbz-3-Pyrrolidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.