Description

Imidazo[1,2-A]Pyridine, 3-Bromo-7-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a bromo-substituent for further functionalization with a trifluoromethyl group known to enhance metabolic stability and lipophilicity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients. Its precise structure makes it a critical intermediate for developing targeted therapies and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental profile.
• Material Science Precursor: Acts as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or components for conductive polymers.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex molecular architectures.
• Fluorine Chemistry Library Synthesis: A valuable component for constructing diverse compound libraries focused on fluorine-containing molecules for screening in drug discovery.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine, 3-Bromo-7-(Trifluoromethyl)-
CAS No.	1263058-72-5
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyridine; 7-(Trifluoromethyl)-3-bromoimidazo[1,2-a]pyridine; 3-Bromo-7-trifluoromethylimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 3-bromo-7-(trifluoromethyl)-; 1263058-72-5; AI3-63235; ZINC000253949793; SCHEMBL21808427
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyridine, 3-Bromo-7-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality ensures the material meets the stringent requirements for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.