Description

4-(2-Amino-5-Bromo-Pyridin-3-Yl)-2-Methyl-But-3-Yn-2-O is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine and alkyne functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Oncology Drug Development: Serves as a precursor for potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Synthesis: Employed in the research and development of new compounds targeting neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Used in university and institutional labs for heterocyclic chemistry and synthetic methodology studies.
• Fine Chemical Production: A valuable intermediate for manufacturing specialized, high-value organic compounds.

Basic Information

Product Name	4-(2-Amino-5-Bromo-Pyridin-3-Yl)-2-Methyl-But-3-Yn-2-O
CAS No.	1262985-25-0
Molecular Formula	C10H11BrN2O
Molecular Weight	255.11 g/mol
Synonyms	2-Methyl-4-(2-amino-5-bromo-3-pyridinyl)-3-butyn-2-ol; 4-(2-Amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol; 3-Butyn-2-ol, 4-(2-amino-5-bromo-3-pyridinyl)-2-methyl-; 2-Methyl-4-(2-amino-5-bromo-3-pyridinyl)-3-butyn-2-ol; 5-Bromo-3-(1-hydroxy-1-methyl-2-propynyl)-2-pyridinamine
EINECS	Contact for details

Quality Control

Our 4-(2-Amino-5-Bromo-Pyridin-3-Yl)-2-Methyl-But-3-Yn-2-O is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.