Description

3-Chloro-5-Difluoromethoxy-Pyridine-2-Carbonitrile is a high-value, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogenated and nitrile-substituted structure makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its difluoromethoxy and nitrile functionalities.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functional polymers, liquid crystals, and electronic materials due to its aromatic pyridine core and electron-withdrawing groups.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Chloro-5-Difluoromethoxy-Pyridine-2-Carbonitrile
CAS No.	1262860-73-0
Molecular Formula	C7H3ClF2N2O
Molecular Weight	204.56 g/mol
Synonyms	2-Cyano-3-chloro-5-(difluoromethoxy)pyridine; 3-Chloro-5-(difluoromethoxy)picolinonitrile; 5-(Difluoromethoxy)-3-chloropicolinonitrile; 2-Pyridinecarbonitrile, 3-chloro-5-(difluoromethoxy)-; 3-Chloro-5-difluoromethoxypyridine-2-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Difluoromethoxy-Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.