Description

5-(Difluoromethoxy)-3-Methylpicolinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted picolinic acid structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries engaged in developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the biological activity of the difluoromethoxy group.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Precursor: Potential use in creating specialized ligands for metal catalysis or as a precursor for functional materials.

Basic Information

Product Name	5-(Difluoromethoxy)-3-Methylpicolinic Acid
CAS No.	1262860-50-3
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	3-Methyl-5-(difluoromethoxy)picolinic acid; 5-(Difluoromethoxy)-3-methylpyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-(difluoromethoxy)-3-methyl-; 1262860-50-3; 5-Difluoromethoxy-3-methyl-picolinic acid
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethoxy)-3-Methylpicolinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.