Description

tert-Butyl 3-Bromo-2-Fluorobenzoate is a high-purity, multi-functional chemical intermediate essential for advanced organic synthesis. This compound matters because its unique halogenated benzoate structure, featuring bromine and fluorine substituents, provides versatile reactivity for constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, agrochemical development, and materials science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) prevalent in modern organic chemistry.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its aromatic and halogenated properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	tert-Butyl 3-Bromo-2-Fluorobenzoate
CAS No.	1262834-58-1
Molecular Formula	C11H12BrFO2
Molecular Weight	275.12 g/mol
Synonyms	3-Bromo-2-fluorobenzoic acid tert-butyl ester; Benzoic acid, 3-bromo-2-fluoro-, 1,1-dimethylethyl ester; tert-Butyl 3-bromo-2-fluorobenzoate; 1,1-Dimethylethyl 3-bromo-2-fluorobenzoate; 2-Fluoro-3-bromobenzoic acid tert-butyl ester; TB 3-Br-2-F-Bz; 3-Bromo-2-fluorobenzoic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-2-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent lot-to-lot quality. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specification parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.