Description

n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoate is a highly reactive, perfluorinated active ester reagent designed for efficient bioconjugation and surface modification. Its core value lies in introducing a long, hydrophobic, and chemically inert perfluoroalkyl chain to target molecules, imparting unique properties like enhanced stability, lipophobicity, and fluorophilicity. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science, where precise labeling and functionalization are critical.

Application

• Bioconjugation Reagent: Primary use for labeling peptides, proteins, and antibodies with a perfluorinated tag for mass spectrometry, imaging, or purification.
• Surface Functionalization: Modification of glass, silicon, or polymer surfaces to create hydrophobic, low-energy, or fluorophilic coatings.
• Fluorous Tagging: Synthesis of fluorous-tagged molecules for simplified purification via fluorous solid-phase extraction (F-SPE).
• Proteomic Research: Selective modification of amine groups in proteins for structural studies or interaction analysis.
• Diagnostic Assay Development: Conjugation to detection probes or solid supports in immunoassays and biosensors.
• Polymer Chemistry: Incorporation of perfluoroalkyl segments into polymers to alter surface properties and stability.
• Linker for Drug Delivery Systems: Creating cleavable or stable linkages in antibody-drug conjugates (ADCs) or nanoparticle formulations.

Basic Information

Product Name	n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoate
CAS No.	1262770-54-6
Molecular Formula	C₁₃H₈F₁₃NO₄
Molecular Weight	489.19 g/mol
Synonyms	NHS Ester of Perfluorononanoic Acid; N-Hydroxysuccinimide Ester of 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoic Acid; Perfluorononanoyloxy Succinimide; 2,5-Dioxopyrrolidin-1-yl 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoate; Tridecafluorononanoic Acid N-Hydroxysuccinimide Ester; PFNA-NHS; C9-Perfluoro NHS Ester; 1-[(Perfluorononanoyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic and moisture-sensitive nature. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.