Description

(S)-tert-Butyl 6-(Hydroxymethyl)-5-Azaspiro[2.4]Heptane-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research and development teams and process chemists in the pharmaceutical and biotechnology industries for the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of proprietary drug candidates, particularly those targeting the central nervous system.
• API Development: Serves as a core structural component for constructing novel molecules with potential therapeutic activity in preclinical and clinical research.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing of complex organic molecules under GMP conditions.
• Asymmetric Synthesis: Leverages its defined (S)-configuration for the stereoselective construction of molecules where chirality is crucial for biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to improve drug-like properties.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for the production of client-specific advanced intermediates.

Basic Information

Product Name	(S)-tert-Butyl 6-(Hydroxymethyl)-5-Azaspiro[2.4]Heptane-5-Carboxylate
CAS No.	1262397-12-5
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-methanol; (S)-tert-Butyl 6-(hydroxymethyl)-5-azaspiro[2.4]heptane-5-carboxylate; 5-Azaspiro[2.4]heptane-6-methanol, 5-(1,1-dimethylethoxy)carbonyl-, (5S)-; (S)-Boc-Protected 5-Azaspiro[2.4]heptane-6-methanol; (S)-6-(Hydroxymethyl)-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 6-(Hydroxymethyl)-5-Azaspiro[2.4]Heptane-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive specifications are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.