Description

(S)-tert-Butyl 5-(Hydroxymethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate CAS NO 1262396-34-8 is a high-value, chiral spirocyclic building block of significant interest in modern pharmaceutical research and development. Its unique structural motif, combining a constrained azaspiro[2.5]octane scaffold with a hydroxymethyl handle, makes it a versatile intermediate for constructing complex bioactive molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates, particularly those targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational rigidity and modulate physicochemical properties of drug-like molecules.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of clinical trial materials and commercial APIs under Good Manufacturing Practice (GMP) standards.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure can be incorporated into linker designs for bifunctional molecules due to the spirocyclic constraint and functional handles.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for target validation and mechanistic studies in biological systems.
• Asymmetric Synthesis: Acts as a chiral template or auxiliary in stereoselective synthetic routes to access enantiomerically pure compounds.

Basic Information

Item	Details
Product Name	(S)-tert-Butyl 5-(Hydroxymethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1262396-34-8
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	(S)-tert-Butyl 5-(hydroxymethyl)-6-azaspiro[2.5]octane-6-carboxylate; 6-azaspiro[2.5]octane-6-carboxylic acid, 5-(hydroxymethyl)-, 1,1-dimethylethyl ester, (5S)-; tert-Butyl (5S)-5-(hydroxymethyl)-6-azaspiro[2.5]octane-6-carboxylate; (S)-5-(Hydroxymethyl)-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; (S)-Boc-6-azaspiro[2.5]octane-5-methanol; Chiral Azaspiro[2.5]octane Building Block
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 5-(Hydroxymethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including Chiral HPLC for enantiomeric excess verification and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.