Description

(S)-6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to introduce constrained, three-dimensional molecular frameworks into their lead compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents.
• Protease Inhibitor Synthesis: Used in constructing the core scaffolds of protease inhibitors for antiviral applications.
• CNS Drug Discovery: Serves as a privileged structure in the synthesis of compounds targeting neurological disorders.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective chemical transformations.
• Chemical Biology Probes: Employed in the development of tool compounds for target validation and mechanistic studies.
• Process Chemistry: Scalable intermediate for the commercial manufacturing of APIs under GMP conditions.

Basic Information

Product Name	(S)-6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-5-Carboxylic Acid
CAS No.	1262396-32-6
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	(S)-6-(Boc)-6-Azaspiro[2.5]Octane-5-Carboxylic Acid; (5S)-6-[(2-Methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-5-carboxylic Acid; (S)-N-Boc-6-Azaspiro[2.5]Octane-5-Carboxylic Acid; tert-Butyl (5S)-5-carboxy-6-azaspiro[2.5]octane-6-carboxylate; Boc-6-Azaspiro[2.5]Octane-5-Carboxylic Acid (S-enantiomer); 6-Azaspiro[2.5]Octane-5-Carboxylic Acid, 6-[(1,1-Dimethylethoxy)carbonyl]-, (5S)-; (S)-Boc-6-Azaspiro[2.5]Octane-5-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our (S)-6-(tert-Butoxycarbonyl)-6-Azaspiro[2.5]Octane-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical R&D and scale-up. Comprehensive Certificates of Analysis (COA) with full chromatographic data are provided to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.