Description

T-Butyl 3-((6-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yloxy)Methyl)Pyrrol is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critically important as a key building block in modern medicinal chemistry, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, antiviral, and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the pyridine ring and various aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring complex heterocyclic architectures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of bifunctional molecules for targeted protein degradation research.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening (HTS) in lead identification.

Basic Information

Product Name	T-Butyl 3-((6-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yloxy)Methyl)Pyrrol
CAS No.	1262133-83-4
Molecular Formula	C20H30BClN2O3
Molecular Weight	392.73 g/mol
Synonyms	tert-Butyl 3-((6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yloxy)methyl)pyrrolidine-1-carboxylate; 1-Boc-3-((6-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yloxy)methyl)pyrrolidine; 3-((6-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-((6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yloxy)methyl)pyrrolidine; 1262133-83-4; Boronic ester intermediate CAS 1262133-83-4
EINECS	Contact for details

Quality Control

Every batch of T-Butyl 3-((6-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yloxy)Methyl)Pyrrol is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity, identity, and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.