Description

tert-Butyl 2,4-Dichloronicotinate is a high-purity chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a versatile building block for constructing complex heterocyclic molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by research and development chemists and process scale-up teams working on active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing functionalized pyridine or nicotinic acid cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the dichloronicotinate moiety is a critical structural component.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and functional materials requiring specific chlorinated heterocyclic structures.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for introducing the nicotinate group into more complex molecular architectures.

Basic Information

Product Name	tert-Butyl 2,4-Dichloronicotinate
CAS No.	1262132-92-2
Molecular Formula	C10H11Cl2NO2
Molecular Weight	248.11 g/mol
Synonyms	2,4-Dichloronicotinic Acid tert-Butyl Ester; tert-Butyl 2,4-Dichloropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2,4-dichloro-, 1,1-dimethylethyl ester; 2,4-Dichloro-3-pyridinecarboxylic acid tert-butyl ester; 1,1-Dimethylethyl 2,4-dichloro-3-pyridinecarboxylate; 2,4-Dichloropyridine-3-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloronicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.