Description

6-(5-Fluoro-2-Methylphenyl)Picolinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct picolinic acid core substituted with a fluorinated aromatic ring. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies, particularly in oncology and other disease areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis Building Block: Used in organic synthesis to introduce the 6-(5-fluoro-2-methylphenyl)picolinoyl moiety into larger, more complex molecules.
• Agrochemical Research: Potential application as an intermediate in the development of new generation herbicides or fungicides with specific activity.
• Material Science: Can be investigated as a monomer or ligand for creating specialized polymers or metal-organic frameworks (MOFs).

Basic Information

Product Name	6-(5-Fluoro-2-Methylphenyl)Picolinic Acid
CAS No.	1261896-76-7
Molecular Formula	C₁₃H₁₀FNO₂
Molecular Weight	231.22 g/mol
Synonyms	6-(5-Fluoro-2-methylphenyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 6-(5-fluoro-2-methylphenyl)-; 6-(5-Fluoro-o-tolyl)picolinic acid; 2-(5-Fluoro-2-methylphenyl)isonicotinic acid (isomer); 6-(5-Fluoro-2-methylphenyl)-2-pyridinecarboxylic acid; 1261896-76-7; 5-Fluoro-2-methylphenyl picolinic acid derivative
EINECS	Contact for details

Quality Control

Every batch of 6-(5-Fluoro-2-Methylphenyl)Picolinic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and oxidizing agents. The compound is soluble in organic solvents; ensure containers are properly sealed to prevent solvent evaporation or moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.