Description

Methyl 4-Chloro-3,5-Difluorobenzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro and chloro substituents contribute to biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers with enhanced thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to introduce functionalized benzoate groups.
• Chemical Research & Development: A valuable scaffold for exploring new chemical entities in academic and industrial research laboratories.

Basic Information

Product Name	Methyl 4-Chloro-3,5-Difluorobenzoate
CAS No.	1261869-25-3
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	Methyl 4-chloro-3,5-difluorobenzoate; Benzoic acid, 4-chloro-3,5-difluoro-, methyl ester; 4-Chloro-3,5-difluorobenzoic acid methyl ester; Methyl 4-chloro-3,5-difluorobenzoate; 3,5-Difluoro-4-chlorobenzoic acid methyl ester; Methyl 3,5-difluoro-4-chlorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 4-Chloro-3,5-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and sources of fluoride ions. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.