Description

Methyl 2-Chloro-4,6-Difluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by R&D chemists and process development scientists working on active ingredients, specialty chemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorobenzene motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro-difluoro substitution pattern confers specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated to introduce fluorine atoms into polymer chains, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and development candidates.

Basic Information

Product Name	Methyl 2-Chloro-4,6-Difluorobenzoate
CAS No.	1261869-14-0
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-Chloro-4,6-difluorobenzoic acid methyl ester; Methyl 2-chloro-4,6-difluorobenzoate; Benzoic acid, 2-chloro-4,6-difluoro-, methyl ester; Methyl 2-chloro-4,6-difluorobenzoate; 2-Chloro-4,6-difluorobenzoic Acid Methyl Ester; Methyl 2-chloro-4,6-difluorobenzoate (CAS 1261869-14-0); Methyl α-chloro-γ,ε-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-4,6-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.