Description

2-(Difluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a difluoromethyl-substituted pyrrolopyridine scaffold, is engineered to modulate the physicochemical and metabolic properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in medicinal chemistry programs, particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and stability.
• Material Science Precursor: Serves as a specialized building block for developing organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Fluorine Chemistry: An essential reagent for introducing the difluoromethyl (CF2H) moiety, a valuable bioisostere for hydroxyl, thiol, or carbonyl groups, into diverse molecular architectures.
• Contract Research & Development (CRO/CMO): Supplied to custom synthesis and process development organizations supporting client projects in drug discovery and fine chemical production.

Basic Information

Product Name	2-(Difluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1261844-48-7
Molecular Formula	C9H6F2N2
Molecular Weight	180.16 g/mol
Synonyms	2-(Difluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 2-(Difluoromethyl)-7-azaindole; 2-(Difluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 2-(difluoromethyl)-; 2-(Difluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 7-Azaindole, 2-(difluoromethyl)-; 2-CF2H-7-azaindole
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profile. Our quality protocols are designed to support regulatory filings in pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to prevent degradation. This material is moisture-sensitive; handle and store under dry conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.