Description

3-(4-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core and trifluoromethoxy-substituted phenyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly for central nervous system (CNS) and inflammatory targets.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in CNS and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and pesticides, leveraging its unique fluorine-containing moiety.
• Material Science Precursor: Serves as a starting material for the synthesis of specialized ligands, catalysts, and organic electronic materials.
• Academic & Industrial R&D: Employed in chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Fluorinated Compound Synthesis: Acts as a versatile building block for introducing the trifluoromethoxyphenyl motif into more complex molecular architectures.

Basic Information

Product Name	3-(4-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine
CAS No.	1261840-25-8
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-Amino-3-[4-(trifluoromethoxy)phenyl]pyridine; 3-(4-(Trifluoromethoxy)phenyl)-4-pyridinamine; 4-Pyridinamine, 3-[4-(trifluoromethoxy)phenyl]-; 3-(4-Trifluoromethoxyphenyl)pyridin-4-ylamine; 1261840-25-8; 3-(4-(Trifluoromethoxy)phenyl)-4-aminopyridine
EINECS	Contact for details

Quality Control

Our 3-(4-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.