Description

2-(Difluoromethoxy)-5-(2-(Trifluoromethoxy)Phenyl)Pyridine is a high-value, multi-fluorinated heterocyclic compound designed for advanced chemical synthesis. This specialized intermediate is critical for researchers and manufacturers developing novel active ingredients, particularly in the pharmaceutical and agrochemical sectors. Its unique structure, featuring both difluoromethoxy and trifluoromethoxyphenyl groups, makes it an essential building block for creating compounds with enhanced metabolic stability, bioavailability, and lipophilicity. Key industries requiring this material include pharmaceutical R&D, agrochemical development, and advanced material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where fluorination improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its fluorinated aromatic system.
• Chemical Biology Probes: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring complex fluorinated pyridine derivatives.

Basic Information

Product Name	2-(Difluoromethoxy)-5-(2-(Trifluoromethoxy)Phenyl)Pyridine
CAS No.	1261836-74-1
Molecular Formula	C13H8F5NO2
Molecular Weight	305.20 g/mol
Synonyms	5-[2-(Trifluoromethoxy)phenyl]-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-[2-(trifluoromethoxy)phenyl]pyridine; Pyridine, 2-(difluoromethoxy)-5-[2-(trifluoromethoxy)phenyl]-; 1261836-74-1
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-5-(2-(Trifluoromethoxy)Phenyl)Pyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include critical parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.