Description

2-Methoxy-5-[4-(Trifluoromethoxy)Phenyl]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core substituted with methoxy and trifluoromethoxy-phenyl groups. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific electronic and steric properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs.
• Chemical Biology Probes: Utilized as a core structure for designing molecular probes and inhibitors for biochemical and pharmacological studies.

Basic Information

Product Name	2-Methoxy-5-[4-(Trifluoromethoxy)Phenyl]Pyridine
CAS No.	1261831-77-9
Molecular Formula	C13H10F3NO2
Molecular Weight	269.22 g/mol
Synonyms	5-[4-(Trifluoromethoxy)phenyl]-2-methoxypyridine; 2-Methoxy-5-(4-trifluoromethoxyphenyl)pyridine; 2-Methoxy-5-(4-(trifluoromethoxy)phenyl)pyridine; 1261831-77-9; 5-(4-Trifluoromethoxyphenyl)-2-methoxypyridine; Pyridine, 2-methoxy-5-[4-(trifluoromethoxy)phenyl]-; 2-Methoxy-5-(α,α,α-trifluoro-p-tolyloxy)pyridine
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-[4-(Trifluoromethoxy)Phenyl]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.