Description

2-Hydroxy-3-(Trifluoromethyl)Phenylisocyanate is a specialized aromatic isocyanate derivative characterized by the presence of both a reactive isocyanate group and a hydroxyl group on the benzene ring, which is further substituted with a trifluoromethyl group. This unique bifunctional structure makes it a high-value building block for synthesizing complex heterocycles and functional polymers with tailored properties. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials research and development teams seeking to incorporate fluorinated motifs and urethane linkages into novel compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated benzoxazinone, quinazolinone, or urea derivatives for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing polyurethanes, polyisocyanurates, and coatings with specific chemical resistance, adhesion, and low surface energy properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create chelating ligands or metal-organic frameworks (MOFs) with unique coordination sites.
• Chemical Research: A versatile reagent for constructing diverse heterocyclic scaffolds in medicinal and combinatorial chemistry.

Basic Information

Item	Details
Product Name	2-Hydroxy-3-(Trifluoromethyl)Phenylisocyanate
CAS No.	1261776-60-6
Molecular Formula	C8H4F3NO2
Molecular Weight	203.12 g/mol
Synonyms	3-(Trifluoromethyl)-2-hydroxyphenyl isocyanate; 2-Isocyanato-6-(trifluoromethyl)phenol; (2-Hydroxy-3-trifluoromethylphenyl)isocyanate; 2-Hydroxy-α,α,α-trifluoro-m-tolyl isocyanate; 2-Hydroxy-3-(trifluoromethyl)benzenisocyanate; 3-Trifluoromethylsalicyloyl isocyanate
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-3-(Trifluoromethyl)Phenylisocyanate is manufactured and tested under strict quality management protocols. We ensure high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, GC, NMR, and FTIR. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and polymerization. Keep away from strong acids, bases, and sources of heat or ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.