Description

5-(2-(Trifluoromethyl)Phenyl)Pyridine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core and trifluoromethylphenyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of small molecule drugs, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in oncology and central nervous system (CNS) therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for ligands and functional organic molecules used in catalysis and electronic materials.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production.

Basic Information

Product Name	5-(2-(Trifluoromethyl)Phenyl)Pyridine-3-Carbonitrile
CAS No.	1261770-60-8
Molecular Formula	C13H7F3N2
Molecular Weight	248.21 g/mol
Synonyms	3-Cyano-5-[2-(trifluoromethyl)phenyl]pyridine; 5-[2-(Trifluoromethyl)phenyl]nicotinonitrile; 5-(2-Trifluoromethylphenyl)-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 5-[2-(trifluoromethyl)phenyl]-; 5-(α,α,α-Trifluoro-o-tolyl)nicotinonitrile
EINECS	Contact for details

Quality Control

Our production of 5-(2-(Trifluoromethyl)Phenyl)Pyridine-3-Carbonitrile adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods such as HPLC, GC, and NMR. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.