Description

2-(Difluoromethoxy)-5-(2,3-Difluorophenyl)Pyridine is a high-purity fluorinated pyridine derivative, a key advanced intermediate in modern organic synthesis. Its value lies in its unique molecular structure, which is critical for introducing specific fluorinated motifs into target molecules, thereby modulating their physicochemical and biological properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy and difluorophenyl groups enhance metabolic stability and bioavailability.
• Material Science Research: Acts as a monomer or precursor for specialty polymers and liquid crystals, contributing to materials with specific dielectric or optical properties.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological processes and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring precise fluorination patterns for client-specific molecular targets.

Basic Information

Product Name	2-(Difluoromethoxy)-5-(2,3-Difluorophenyl)Pyridine
CAS No.	1261764-07-1
Molecular Formula	C12H7F4NO
Molecular Weight	269.19 g/mol
Synonyms	5-(2,3-Difluorophenyl)-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-(2,3-difluorophenyl)pyridine; 1261764-07-1; 2-Difluoromethoxy-5-(2,3-difluorophenyl)pyridine; 5-(2,3-Difluoro-phenyl)-2-difluoromethoxy-pyridine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our advanced intermediates. Production follows cGMP guidelines where applicable, and every batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.