Description

Methyl 5-(2,3-Difluorophenyl)Pyridine-3-Carboxylate CAS NO 1261663-40-4 is a high-purity, multifunctional heterocyclic building block featuring a difluorophenyl substituent. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents. It is primarily sought by research institutions and manufacturers in the life sciences sector for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluorophenyl and pyridine motifs.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing molecular probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity fluorinated intermediates.

Basic Information

Product Name	Methyl 5-(2,3-Difluorophenyl)Pyridine-3-Carboxylate
CAS No.	1261663-40-4
Molecular Formula	C14H9F2NO2
Molecular Weight	261.22 g/mol
Synonyms	Methyl 5-(2,3-difluorophenyl)nicotinate; 3-Pyridinecarboxylic acid, 5-(2,3-difluorophenyl)-, methyl ester; 5-(2,3-Difluorophenyl)nicotinic acid methyl ester; Methyl 5-(2,3-difluorophenyl)-3-pyridinecarboxylate; 1261663-40-4; Methyl 5-(2,3-difluorophenyl)pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-(2,3-Difluorophenyl)Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.