Description

Methyl 3-(Difluoromethoxy)-4-Fluorobenzoate is a high-value fluorinated aromatic ester building block, essential for synthesizing advanced molecules with tailored properties. Its unique difluoromethoxy and fluoro substituents make it a critical intermediate for introducing specific lipophilicity and metabolic stability into target compounds. This product is primarily needed by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies.
• Organic Electronics: Intermediate in the development of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating novel chemical entities in academic and industrial labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and production under cGMP or ISO standards for client projects.

Basic Information

Product Name	Methyl 3-(Difluoromethoxy)-4-Fluorobenzoate
CAS No.	1261582-03-9
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	3-(Difluoromethoxy)-4-fluorobenzoic acid methyl ester; Methyl 4-fluoro-3-(difluoromethoxy)benzoate; Benzoic acid, 3-(difluoromethoxy)-4-fluoro-, methyl ester; 4-Fluoro-3-(difluoromethoxy)benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-(Difluoromethoxy)-4-Fluorobenzoate is produced and controlled under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, which is critical for your downstream synthesis and regulatory filings. Certificates of Analysis (COA) with detailed HPLC/GC purity, NMR confirmation, and impurity profiles are available for all commercial and R&D quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.