Description

2-(Difluoromethoxy)-5-(4-(Trifluoromethyl)Phenyl)Pyridine is a high-value fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring difluoromethoxy and trifluoromethylphenyl groups, makes it indispensable for introducing fluorine motifs to enhance the potency and metabolic stability of target molecules. This compound is primarily sought by pharmaceutical and agrochemical R&D sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials that require specific fluorinated aromatic systems.
• Chemical Biology & Probe Development: Employed in creating molecular probes and tags for studying biological processes and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital substrate for fine chemical manufacturers offering bespoke synthesis services for client-specific molecular entities.

Basic Information

Product Name	2-(Difluoromethoxy)-5-(4-(Trifluoromethyl)Phenyl)Pyridine
CAS No.	1261564-51-5
Molecular Formula	C13H8F5NO
Molecular Weight	289.20 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-5-[4-(trifluoromethyl)phenyl]pyridine; 2-Difluoromethoxy-5-(4-trifluoromethylphenyl)pyridine; 2-(Difluoromethoxy)-5-(4-trifluoromethylphenyl)pyridine; 1261564-51-5
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-5-(4-(Trifluoromethyl)Phenyl)Pyridine is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Our standard quality commitment includes rigorous purity analysis by HPLC/GC, identity confirmation via spectroscopic methods (NMR, IR, MS), and control of specified impurities. A detailed Certificate of Analysis (COA) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.