Description

4-Chloro-6-Methoxynicotinonitrile is a versatile and high-value pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and methoxy substituents on the nicotinonitrile core, makes it an essential intermediate for constructing complex heterocyclic systems. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its bioactive pyridine scaffold.
• Material Science: Serves as a building block for creating specialized ligands, organic semiconductors, and liquid crystal materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the chloronicotinonitrile moiety into more complex molecules.
• Academic & R&D: Utilized in university and corporate research laboratories for method development and exploring new chemical spaces.

Basic Information

Product Name	4-Chloro-6-Methoxynicotinonitrile
CAS No.	1261493-38-2
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	4-Chloro-6-methoxypyridine-3-carbonitrile; 6-Methoxy-4-chloronicotinonitrile; 3-Cyano-4-chloro-6-methoxypyridine; 4-Chloro-6-methoxy-3-pyridinecarbonitrile; 4-Chloro-6-methoxy-3-cyanopyridine; Nicotinonitrile, 4-chloro-6-methoxy-; 1261493-38-2
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Methoxynicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.