Description

4-Chloro-5-Iodo-2-Methoxy-Pyridine is a high-value halogenated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use in drug discovery programs and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-deficient pyridine core.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, enabling complex molecular architecture.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and enzyme inhibitors for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Chloro-5-Iodo-2-Methoxy-Pyridine
CAS No.	1261488-16-7
Molecular Formula	C6H5ClINO
Molecular Weight	269.47 g/mol
Synonyms	2-Methoxy-4-chloro-5-iodopyridine; 5-Iodo-4-chloro-2-methoxypyridine; 4-Chloro-5-iodo-2-methoxypyridine; 4-Chloro-2-methoxy-5-iodopyridine; Pyridine, 4-chloro-5-iodo-2-methoxy-; 1261488-16-7; 4-Chloro-5-iodo-2-methoxypyridine (CAS 1261488-16-7)
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-2-Methoxy-Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.