Description

Methyl 4-Chloro-3-(trifluoromethoxy)benzoate is a high-value fluorinated aromatic ester building block, essential for advanced organic synthesis. Its unique structure, combining chloro and trifluoromethoxy substituents, provides significant electronic and steric properties that are critical for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial precursor in the design and production of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Liquid Crystal Materials: Used in the synthesis of fluorinated liquid crystal compounds for advanced display technologies, leveraging its aromatic core and fluorine content.
• Organic Electronic Materials: Acts as a building block for electron-deficient moieties in the development of organic semiconductors and charge-transport materials.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical manufacturers for bespoke synthesis projects requiring specific fluorinated aromatic architectures.
• Chemical Research: Utilized in academic and industrial laboratories to study structure-activity relationships (SAR) and novel fluorination effects in medicinal and materials chemistry.

Basic Information

Product Name	Methyl 4-Chloro-3-(trifluoromethoxy)benzoate
CAS No.	1261444-00-1
Molecular Formula	C9H6ClF3O3
Molecular Weight	254.59 g/mol
Synonyms	Benzoic acid, 4-chloro-3-(trifluoromethoxy)-, methyl ester; Methyl 4-chloro-3-[(trifluoromethyl)oxy]benzoate; 4-Chloro-3-(trifluoromethoxy)benzoic acid methyl ester; Methyl 4-chloro-α,α,α-trifluoro-m-anisate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Chloro-3-(trifluoromethoxy)benzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our facilities operate under cGMP principles where applicable, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.