Description

2-Fluoro-1-Iodo-4-Isocyanatobenzene is a versatile and highly reactive aromatic isocyanate building block. Its value lies in the strategic combination of fluorine, iodine, and isocyanate functional groups, enabling precise molecular construction for advanced materials and pharmaceuticals. This compound is essential for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and the creation of specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex bioactive molecules, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the fluorine and iodine substituents for enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, where its rigid, halogenated aromatic core contributes to desired optical and electronic properties.
• Polymer & Resin Modification: The reactive isocyanate group allows for incorporation into polyurethanes, polyureas, and other polymers to impart specific chemical resistance or mechanical traits.
• Cross-coupling Reactions: The iodine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), facilitating rapid diversification of chemical libraries.
• Chemical Biology & Proteomics: Acts as a labeling or crosslinking agent for probing protein structure and function due to its electrophilic isocyanate moiety.

Basic Information

Product Name	2-Fluoro-1-Iodo-4-Isocyanatobenzene
CAS No.	1261441-79-5
Molecular Formula	C7H3FINO
Molecular Weight	278.96 g/mol
Synonyms	4-Isocyanato-2-fluoro-1-iodobenzene; 1-Fluoro-2-iodo-4-isocyanatobenzene; 2-Fluoro-4-isocyanato-1-iodobenzene; 2-Fluoro-1-iodo-4-isocyanato-Benzene; 2-Fluoro-1-iodobenzene-4-isocyanate; 4-Fluoro-3-iodophenyl isocyanate; 3-Iodo-4-fluorophenyl isocyanate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-1-Iodo-4-Isocyanatobenzene is produced and analyzed under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques, including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.