Description

(E)-Methyl 3-(2,3-Dihydro-[1,4]Dioxino-[2,3-B]Pyridin-7-Yl)Acrylate is a high-purity, advanced pharmaceutical intermediate characterized by its fused dioxino-pyridine heterocyclic core and acrylate ester functionality. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing molecular libraries and exploring structure-activity relationships (SAR) in drug discovery.
• Organic Synthesis: Serves as a Michael acceptor or a dienophile in cycloaddition reactions, enabling the construction of complex polycyclic frameworks.
• Chemical Biology: Employed in the development of molecular probes and tool compounds for target identification and validation studies.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for potential new chemical entities (NCEs).
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations supporting global pharmaceutical development.

Basic Information

Product Name	(E)-Methyl 3-(2,3-Dihydro-[1,4]Dioxino-[2,3-B]Pyridin-7-Yl)Acrylate
CAS No.	1261399-00-1
Molecular Formula	C12H11NO4
Molecular Weight	233.22 g/mol
Synonyms	Methyl (2E)-3-(2,3-dihydro[1,4]dioxino[2,3-b]pyridin-7-yl)prop-2-enoate; 7-[(1E)-3-Methoxy-3-oxo-1-propen-1-yl]-2,3-dihydro[1,4]dioxino[2,3-b]pyridine; (E)-Methyl 3-(2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)acrylate; Methyl trans-3-(2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)acrylate; Dioxinopyridine acrylate ester
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(2,3-Dihydro-[1,4]Dioxino-[2,3-B]Pyridin-7-Yl)Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting standards for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.