Description

5-Chloro-1-(Triisopropylsilyl)-4-((Trimethylsilyl) -Ethynyl)-1H-Pyrrolo[2,3-B]Pyridine is a highly functionalized, organosilicon-protected pyrrolopyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile, protected scaffold for constructing complex heterocyclic systems, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on kinase inhibitors, oncology therapeutics, and other small molecule drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable core.
• Process Chemistry Development: Serves as a pivotal intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Heterocyclic Compound Synthesis: A versatile precursor for constructing complex fused-ring systems and functionalized nitrogen-containing heterocycles.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Material Science: Can be explored as a monomer or functional unit in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	5-Chloro-1-(Triisopropylsilyl)-4-((Trimethylsilyl) -Ethynyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1261365-96-1
Molecular Formula	C22H35ClN2Si2
Molecular Weight	419.16 g/mol
Synonyms	5-Chloro-1-(triisopropylsilyl)-4-[(trimethylsilyl)ethynyl]-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-1-(triisopropylsilyl)-4-[(trimethylsilyl)ethynyl]-; TIPS-Protected Chloro-Ethynyl Pyrrolopyridine; 5-Chloro-4-((trimethylsilyl)ethynyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; CAS 1261365-96-1; 5-Chloro-1-TIPS-4-TMS-ethynyl-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-1-(Triisopropylsilyl)-4-((Trimethylsilyl) -Ethynyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.