Description

5-Chloro-3-Iodopyridin-2-Yl Trifluoromethanesulfonate is a high-value, multi-functional chemical building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of a reactive pyridine scaffold with halogen and triflate leaving groups, enabling precise and efficient cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules for drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Cross-Coupling Reactions: Serves as an excellent substrate for Suzuki-Miyaura, Stille, and Negishi couplings due to the reactive iodine and triflate groups.
• Material Science Research: Employed in the creation of functionalized ligands for catalysis and organic electronic materials.
• Chemical Biology Probes: Utilized to synthesize tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring regioselectively functionalized pyridines.

Basic Information

Product Name	5-Chloro-3-Iodopyridin-2-Yl Trifluoromethanesulfonate
CAS No.	1261365-87-0
Molecular Formula	C7H2ClF3INO3S
Molecular Weight	411.51 g/mol
Synonyms	2-Pyridinol, 5-chloro-3-iodo-, trifluoromethanesulfonate; 5-Chloro-3-iodopyridin-2-yl triflate; 5-Chloro-3-iodo-2-pyridyl trifluoromethanesulfonate; 2-(Trifluoromethanesulfonyloxy)-5-chloro-3-iodopyridine; 5-Chloro-3-iodo-2-(trifluoromethanesulfonyloxy)pyridine; 1261365-87-0; 5-Chloro-3-iodopyridin-2-yl trifluoromethanesulphonate
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-3-Iodopyridin-2-Yl Trifluoromethanesulfonate undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and process chemistry. Our quality assurance protocols include advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive and moisture-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.