Description

4-Iodo-2,3-Dimethoxy-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine, methoxy groups, and a trifluoromethyl substituent, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira) to introduce the pyridine core into complex architectures.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent for bioconjugation and probe development due to its reactive halogen and stable CF3 group.
• Catalyst Ligand Synthesis: Used to prepare novel nitrogen-containing ligands for transition metal catalysis.

Basic Information

Product Name	4-Iodo-2,3-Dimethoxy-5-(Trifluoromethyl)Pyridine
CAS No.	1261365-81-4
Molecular Formula	C8H7F3INO2
Molecular Weight	357.05 g/mol
Synonyms	2,3-Dimethoxy-5-(trifluoromethyl)-4-iodopyridine; 4-Iodo-2,3-dimethoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-4-iodo-2,3-dimethoxypyridine; 4-Iodo-2,3-dimethoxy-5-trifluoromethylpyridine; Pyridine, 4-iodo-2,3-dimethoxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-2,3-Dimethoxy-5-(Trifluoromethyl)Pyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) including results for identity, purity (typically by HPLC or GC), and impurity profile is supplied with each shipment to guarantee reproducible performance and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.