Description

Methyl 5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carboxylate is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a pyrrolopyridine scaffold with a trifluoromethyl group, offering unique electronic and steric properties to modulate the bioactivity and physicochemical profile of target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a privileged scaffold in medicinal chemistry for the synthesis of kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used as a key precursor in developing new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science: Acts as a building block for advanced organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical assays and imaging studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	Methyl 5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carboxylate
CAS No.	1261365-80-3
Molecular Formula	C10H7F3N2O2
Molecular Weight	244.17 g/mol
Synonyms	Methyl 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl methyl ester; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 5-(trifluoromethyl)-, methyl ester; 5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]-Pyridine-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.