Description

4-Methyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional heterocyclic building block containing both a pyrrolopyridine core and a trifluoromethyl group. This compound matters for its unique structural features, which are critical for modulating the physicochemical and pharmacokinetic properties of advanced molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in drug discovery programs targeting CNS disorders and oncology.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new chemical entities, especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Material Science: Serves as a precursor for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology: Employed as a molecular probe or a tagged scaffold in proteomics and bio-conjugation studies.
• Fluorine Chemistry: A valuable building block for introducing the CF3 moiety into complex molecules, leveraging its electron-withdrawing and lipophilicity-enhancing effects.

Basic Information

Product Name	4-Methyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1261365-79-0
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	4-Methyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-methyl-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-methyl-1H-pyrrolo[2,3-b]pyridine; 4-Methyl-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; Pyrrolo[2,3-b]pyridine, 4-methyl-5-(trifluoromethyl)-; CAS 1261365-79-0
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) with full specification data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.