Description

4-Iodo-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular modifications, particularly in the development of complex active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical companies focused on creating novel compounds with specific electronic and steric properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used to construct novel active ingredients for crop protection products, leveraging the stability imparted by the triisopropylsilyl (TIPS) protecting group.
• Material Science: Serves as a building block for organic electronic materials, where the iodine atom allows for further cross-coupling reactions to create extended π-systems.
• Chemical Biology & Probe Development: Employed in creating molecular probes and tags due to the reactivity of the iodine substituent for bioconjugation (e.g., Sonogashira coupling).
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial production of complex molecules requiring this specific substitution pattern.

Basic Information

Product Name	4-Iodo-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1261365-73-4
Molecular Formula	C18H24F3IN2Si
Molecular Weight	480.39 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 4-iodo-5-(trifluoromethyl)-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Iodo-5-trifluoromethyl-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 4-Iodo-5-CF3-7-Azaindole; 1-(Triisopropylsilyl)-4-iodo-5-(trifluoromethyl)-7-azaindole; 4-Iodo-5-(trifluoromethyl)-1-[(triisopropylsilyl)]-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 4-Iodo-5-(Trifluoromethyl)-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and handled under inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.