Description

5-Fluoro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a highly functionalized, organosilicon-protected pyrrolopyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the strategic placement of halogen and silyl protecting groups, enabling precise, multi-step synthesis of complex heterocyclic targets. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for creating organic electronic materials, such as semiconductors or light-emitting components.
• Chemical Synthesis: Acts as a versatile scaffold for constructing complex, fused heterocyclic systems in academic and industrial R&D.
• Protecting Group Strategy: The triisopropylsilyl (TIPS) and trimethylsilyl (TMS) groups allow for selective deprotection and further functionalization in multi-step synthetic routes.

Basic Information

Product Name	5-Fluoro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1261365-70-1
Molecular Formula	C21H34FIN2Si2
Molecular Weight	524.46 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-6-iodo-1-(triisopropylsilyl)-4-(trimethylsilyl)-; 5-Fluoro-6-iodo-1-(triisopropylsilyl)-4-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-6-iodo-1-TIPS-4-TMS-1H-pyrrolo[2,3-b]pyridine; TIPS/TMS-protected fluoroiodopyrrolopyridine; Fluorinated iodopyrrolopyridine silyl ether
EINECS	Contact for details

Quality Control

Our production of 5-Fluoro-6-Iodo-1-(Triisopropylsilyl)-4-(Trimethylsilyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.