Description

7-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine is a high-value, organosilicon-protected alkyne derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in enabling efficient Sonogashira and other cross-coupling reactions, providing a stable handle for the controlled introduction of an ethynyl group into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides that require specific alkyne-functionalized heterocyclic cores.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of conjugated polymers and organic electronic materials.
• Chemical Biology Probe Development: Employed in click chemistry (CuAAC) applications to create labeled molecules for target identification and binding studies.
• Ligand Synthesis for Catalysis: Used to construct sophisticated ligand frameworks for transition metal catalysts used in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodology development and complex natural product synthesis in R&D laboratories.

Basic Information

Product Name	7-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine
CAS No.	1261365-41-6
Molecular Formula	C14H19NO2Si
Molecular Weight	261.40 g/mol
Synonyms	2,3-Dihydro-[1,4]dioxino[2,3-b]pyridine, 7-[(trimethylsilyl)ethynyl]-; 7-(Trimethylsilylethynyl)-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 7-((Trimethylsilyl)ethynyl)-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 7-Ethynyl-2,3-dihydro-1,4-dioxino[2,3-b]pyridine, TMS-protected; TMS-protected 7-ethynyl-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 1,4-Dioxino[2,3-b]pyridine, 7-[(trimethylsilyl)ethynyl]-2,3-dihydro-; CAS 1261365-41-6
EINECS	Contact for details

Quality Control

Our production of 7-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by NMR (1H, 13C), HPLC, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting compliance with internal quality standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.