Description

5-Bromo-6-Methoxypyridine-2-Carbonitrile is a versatile and high-value brominated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both bromine and nitrile functional groups, makes it an essential building block for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands used in catalysis and material science.
• Functional Material Development: Employed in the research of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to introduce diverse aryl/heteroaryl groups.
• Nitrile Functionalization: The cyano group can be transformed into amides, acids, tetrazoles, and other valuable functional groups, expanding its utility in medicinal chemistry.

Basic Information

Product Name	5-Bromo-6-Methoxypyridine-2-Carbonitrile
CAS No.	1261269-71-9
Molecular Formula	C7H5BrN2O
Molecular Weight	213.04 g/mol
Synonyms	2-Cyano-5-bromo-6-methoxypyridine; 5-Bromo-6-methoxy-2-pyridinecarbonitrile; 6-Methoxy-5-bromopicolinonitrile; 5-Bromo-6-methoxypicolinonitrile; 2-Pyridinecarbonitrile, 5-bromo-6-methoxy-; 5-Bromo-6-methoxypyridine-2-carbonitrile; 1261269-71-9
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Methoxypyridine-2-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.